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2.7 LCMS/MS analysis and data preprocessing A UHPLC system (Vanquish, Thermo Fisher Scientific) with a UPLC HSS T3 column coupled to an Orbitrap Exploris 120 mass spectrometer (Orbitrap MS, Thermo) was employed to perform LCMS/MS analysis

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A deregulation of catalase levels in individuals with diabetes has been reported, with reduced activity observed in tissues like the pancreas and liver associated with hyperglycemic conditions [79,80]

However, ICIs can cause immune-related side effects (irAEs) by impairing peripheral immunological tolerance, and the endocrine glands are among the organs most frequently impacted

Credit : Dr Dan Gubler Delicious, who are they trying to kid